"In acute lymphoblastic leukaemia, the lymphoid progenitor cells, also known as lymphoblasts, do not mature due to abnormal expression of genes, often as a result of chromosomal abnormalities or chromosomal translocations (e.g. BCR-ABL1). The proliferation of primitive cells occupies an increasing amount of marrow space at the expense of normal haematopoietic elements, resulting in a decrease in the production of normal blood cells and bone marrow failure. Eventually, the lymphoblasts spill into the blood and can affect the liver, spleen, central nervous system, and lymph nodes."
"The exact treatment regimens used in managing ALL are beyond the scope of this article, but depend on factors such as whether the disease is B or T cell ALL, and whether positive or negative for BCR-ABL1 fusion."