"NPM1 mutations occur in ~30% of of adult AML, and are considered AML-specific 1,2. Its occurrence is less in childhood AML cases."
"NPM1 is a ubiquitous and abundant protein that resides in the nucleoli under normal physiologic conditions but continuously shuttles between the nucleus and the cytoplasm. A mutation in the gene encoding nucleophosmin (NPM1) is detected genomic alterations in this subtype of AML."
"NPM1-mutated AMLs is considered globally chemosensitive, with complete remission rates nearing 90% although with heterogeneity in relapse rates."