"It represents a failure of apoptotic mechanisms to maintain lymphocyte homoeostasis and is a rare inherited disorder most commonly occurring due to mutations in the FAS (TNFRSF6) gene. Other mutations of the genes such as Fas-ligand (FASLG), Caspase 10 (CASP10) and Caspase 8 (CASP8), NRAS and KRAS have also been observed in small numbers of patients and approximately 20-30% of patients may have an unidentified defect 6."
"It represents a failure of apoptotic mechanisms to maintain lymphocyte homoeostasis and is a rare inherited disorder most commonly occurring due to mutations in the FAS (TNFRSF6) gene. Other mutations of the genes such as Fas-ligand (FASLG), Caspase 10 (CASP10) and Caspase 8 (CASP8), NRAS and KRAS have also been observed in small numbers of patients and approximately 20-30% of patients may have an unidentified defect 6."
"It represents a failure of apoptotic mechanisms to maintain lymphocyte homoeostasis and is a rare inherited disorder most commonly occurring due to mutations in the FAS (TNFRSF6) gene. Other mutations of the genes such as Fas-ligand (FASLG), Caspase 10 (CASP10) and Caspase 8 (CASP8), NRAS and KRAS have also been observed in small numbers of patients and approximately 20-30% of patients may have an unidentified defect 6."
Expected headings
"Complications"
"It represents a failure of apoptotic mechanisms to maintain lymphocyte homoeostasis and is a rare inherited disorder most commonly occurring due to mutations in the FAS (TNFRSF6) gene. Other mutations of the genes such as Fas-ligand (FASLG), Caspase 10 (CASP10) and Caspase 8 (CASP8), NRAS and KRAS have also been observed in small numbers of patients and approximately 20-30% of patients may have an unidentified defect 6."