"Cerebral malaria is mainly encountered in young children and adults living or travelling in malaria-endemic areas. It is estimated to occur in ~2% of patients with acute Plasmodium falciparum infection, the most common species of Plasmodium that causes malaria."
"The haemorrhages are thought to occur when cerebral capillaries and small veins are occluded by sequestered Plasmodium-infected erythrocytes. Hence, this pathological process may lead to areas of infarction."
"Cerebral malaria should be suspected when there are neurological symptoms on a background of malarial infection. Clinical presentations include: headache, altered state of consciousness, seizures, backache, vomiting, nausea, etc."
"T2/FLAIR: non-specific hyperintensities located in the bilateral periventricular white matter, corpus callosum, occipital subcortex, basal, ganglia, and/or bilateral thalamic regions 3,8,10"
"The most common findings are related to ischaemia involving: deep white matter, cortex, basal ganglia, thalami and cerebellum. These areas of ischaemia can be haemorrhagic 6."