"Chronic granulomatous disease (CGD) refers to a heterogeneous group of inherited immune deficiency disorders characterised by the inability to destroy phagocytosed catalase-positive bacteria due to a lack of NADPH oxidase which results in formation of granulomas in different tissues."
"It occurs due to a defective nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. This then results in deficient production of the oxygen radicals needed by phagocytes for intracellular killing of microorganisms in particular catalase-positive bacterias such as S.aureus, Serratia, Klebsiella, Burkholderia, and Aspergillus . It can affect multiple systems although the respiratory system and bones are the most commonly affected. The organ systems that can potentially get affected include lymphatic, hepatic, skeletal, gastrointestinal, genitourinary, head and neck, and central nervous system 5. Diagnosis is by the nitroblue tetrazolium (NBT) slide test, cytometry, or cytochrome C reduction."
"The most common presentation is a young patient with short stature, dermatitis, gingivitis, anaemia of chronic disease, recurrent lymphadenopathy, hepatosplenomegaly, hepatic abscesses and multifocal, recurrent osteomyelitis."
"It occurs due to a defective nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. This then results in deficient production of the oxygen radicals needed by phagocytes for intracellular killing of microorganisms in particular catalase-positive bacterias such as S.aureus, Serratia, Klebsiella, Burkholderia, and Aspergillus . It can affect multiple systems although the respiratory system and bones are the most commonly affected. The organ systems that can potentially get affected include lymphatic, hepatic, skeletal, gastrointestinal, genitourinary, head and neck, and central nervous system 5. Diagnosis is by the nitroblue tetrazolium (NBT) slide test, cytometry, or cytochrome C reduction."
"It occurs due to a defective nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in phagocytes. This then results in deficient production of the oxygen radicals needed by phagocytes for intracellular killing of microorganisms in particular catalase-positive bacterias such as S.aureus, Serratia, Klebsiella, Burkholderia, and Aspergillus . It can affect multiple systems although the respiratory system and bones are the most commonly affected. The organ systems that can potentially get affected include lymphatic, hepatic, skeletal, gastrointestinal, genitourinary, head and neck, and central nervous system 5. Diagnosis is by the nitroblue tetrazolium (NBT) slide test, cytometry, or cytochrome C reduction."