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Lint: currarino-syndrome-1

Acronyms
warning

"The Currarino syndrome is a complex condition variably comprised of characteristic congenital anomalies of the sacrum, anorectum and presacral soft tissues. It is also known as the Currarino triad or ASP triad, however, not all three features are always present 6."

Line 1:277 · 'ASP' has no definition. Spell it out if it's unfamiliar to the audience.

"The triad of features gives rise to the acronym ASP triad (anorectal malformation, sacrococcygeal defect, presacral mass) 1. Since the condition was initially defined as a set of radiographic findings, it was considered an association (like VACTERL)."

Line 22:60 · 'ASP' has no definition. Spell it out if it's unfamiliar to the audience.
Strong
warning

"The triad of features gives rise to the acronym ASP triad (anorectal malformation, sacrococcygeal defect, presacral mass) 1. Since the condition was initially defined as a set of radiographic findings, it was considered an association (like VACTERL)."

Line 22:52 · Generally, don't use bold in text: '<strong>ASP triad</strong>'
Emphasis
warning

"The condition is associated with a mutation of the MNX1 (previously HLXB9) gene 6,7. The mutation is inherited in an autosomal dominant with reduced penetrance and variable expressivity 6."

Line 27:55 · Italics should be used only in exceptional circumstances: '<em>MNX1</em> (previously <em>HLXB9</em>'
Oxford Comma
suggestion

"The Currarino syndrome is a complex condition variably comprised of characteristic congenital anomalies of the sacrum, anorectum and presacral soft tissues. It is also known as the Currarino triad or ASP triad, however, not all three features are always present 6."

Line 1:152 · Use the Oxford comma in 'sacrum, anorectum and presacral'.