"In high-risk pregnancies, there is an increased incidence of aneuploidy (e.g. Down syndrome 2,3 and trisomy 13 3) and it is classified as a soft marker. The presence of multiple or bilateral (more than one chamber) echogenic foci is considered to increase the risk."
Expected headings
"Associations"
"When seen incidentally in isolation in a normal pregnancy, it is considered a benign variant and some authors state karyotyping is unwarranted in the mid-trimester 8. There is no recognised direct association with congenital heart anomalies for an isolated echogenic intracardiac focus 1 (unless there is an associated aneuploidic anomaly)."