"Histologically, there is often dense fibrous tissue, fatty replacement, muscular atrophy, dysplastic veins and lymphoplasmacytic aggregates in the skeletal muscle. Small lymphatic malformations can be also associated, as can thrombi and phleboliths. It is caused by an activating somatic mutation in PIK3CA, and some authors consider it part of the PIK3CA-related overgrowth spectrum (PROS) 5."
"PTEN hamartoma of soft tissue (PHOST): patients usually have other features of a syndromic PTEN-related disease such as Bannayan-Riley-Ruvalcaba syndrome or Cowden syndrome"
"Histologically, there is often dense fibrous tissue, fatty replacement, muscular atrophy, dysplastic veins and lymphoplasmacytic aggregates in the skeletal muscle. Small lymphatic malformations can be also associated, as can thrombi and phleboliths. It is caused by an activating somatic mutation in PIK3CA, and some authors consider it part of the PIK3CA-related overgrowth spectrum (PROS) 5."
Expected headings
"Radiography"
"Typically, a soft tissue mass is seen centred in skeletal muscle. There is usually fatty replacement of muscle seen as heterogeneous moderately high signal on T1 and T2 weighted images. The lesion usually shows enhancement after gadolinium administration. There can be isolated muscle involvement or transfascial extension with or without subcutaneous involvement. Dilated tortuous veins are often seen within or adjacent the mass with either normal or dilated drainage veins. Reactive bone change can be seen."