"Fundic gland polyps account for ~60% (range 47-77%) of gastric polyps 1-3. They may arise sporadically or be part of the syndrome (e.g. familial adenomatous polyposis), although there are different genetic mutations between sporadic and FAP-associated cases 1,2."
"Fundic gland polyps associated with FAP demonstrate 41% dysplasia and increase the incidence of gastric carcinoma 1."
"The pathogenesis remains unclear, and there may be an association with antacid medications (e.g. proton pump inhibitors) and reduced rates of Helicobacter pylori infections."
"Sporadic fundic gland polyps are generally regarded as benign. There are case reports of low-grade neoplasia, but no cases of gastric carcinoma 1."