"Most tumours demonstrate two histologic patterns, and this is expressed as a Gleason score. The two most common grade patterns seen in a tumour are expressed together and summed. Gleason scores can be expressed as their individual components or as the total Gleason score, eg 3+4=7. The commonest pattern is noted first, hence, a Gleason score of 4+3=7 is more aggressive than a Gleason score of 3+4=7 (by convention, the score numbers and the '+' and '=' symbols are not separated by spaces)."
"The score is named after an American pathologist Donald Floyd Gleason (1920-2008) 4,5. From 1960 to 1964 he reviewed 280 cold cases of prostate carcinoma, from which he was blinded from any clinical details, and identified five histological patterns that were consistently seen. Statisticians at the National Institutes of Health (NIH) amalgamated clinical data with Gleason's work into a scoring system, which they described in 1966. This was validated on a further 4,000 cases by 1974, and the Gleason scale was in ubiquitous usage by the late 1970s 5."
"The Gleason grade, originally described in 1974, describes the histologic pattern of gland arrangement 2."
"The Gleason grade, originally described in 1974, describes the histologic pattern of gland arrangement 2."
"Most tumours demonstrate two histologic patterns, and this is expressed as a Gleason score. The two most common grade patterns seen in a tumour are expressed together and summed. Gleason scores can be expressed as their individual components or as the total Gleason score, eg 3+4=7. The commonest pattern is noted first, hence, a Gleason score of 4+3=7 is more aggressive than a Gleason score of 3+4=7 (by convention, the score numbers and the '+' and '=' symbols are not separated by spaces)."
"Grade group stratification was introduced by the International Society of Urological Pathology (ISUP) 3 and has been adopted by the American Joint Committee on Cancer (AJCC). The Gleason score system is compressed into five Grade Groups as per Table 1."
"Grade group stratification was introduced by the International Society of Urological Pathology (ISUP) 3 and has been adopted by the American Joint Committee on Cancer (AJCC). The Gleason score system is compressed into five Grade Groups as per Table 1."
Expected headings
"Gleason score"
"Gleason grade group"