"Haemoglobin SC (HbSC) disease is a haemoglobinopathy, and a common variant of sickle cell disease (SCD). There is coinheritance of one HbS gene and one HbC gene, resulting in a milder phenotype than full-blown sickle cell disease. It most commonly manifests with a proliferative retinopathy. Painful crises, functional asplenia and osteonecrosis are also frequent sequelae."
"Haemoglobin SC disease makes up almost 30% of cases of sickle cell disease in the United Kingdom and the United States 1. In some regions of West Africa, where the HbC variant arose, HbSC may form more than half of all cases of sickle cell disease 1. Globally more than 50,000 babies with HbSC are born each year."
"In general, haemoglobin SC disease is viewed as a milder variant of sickle cell disease, nevertheless significant morbidity still often results."
"thromboembolism: PE and DVT are more common"
"Inheritance of the haemoglobin S (HbS) and haemoglobin C (HbC) beta globin gene (HBB) mutations together (i.e. coinheritance) results in haemoglobin SC (HbSC) disease."
"Inheritance of the haemoglobin S (HbS) and haemoglobin C (HbC) beta globin gene (HBB) mutations together (i.e. coinheritance) results in haemoglobin SC (HbSC) disease."
"Haemoglobin SC (HbSC) disease is a haemoglobinopathy, and a common variant of sickle cell disease (SCD). There is coinheritance of one HbS gene and one HbC gene, resulting in a milder phenotype than full-blown sickle cell disease. It most commonly manifests with a proliferative retinopathy. Painful crises, functional asplenia and osteonecrosis are also frequent sequelae."
"Inheritance of the haemoglobin S (HbS) and haemoglobin C (HbC) beta globin gene (HBB) mutations together (i.e. coinheritance) results in haemoglobin SC (HbSC) disease."