"The disease progresses rapidly, with a mean illness duration of about 4–6 months from onset to death 4,5."
"Most Heidenhain variant cases are sporadic, but rare genetic forms exist, often associated with PRNP mutations such as V210I 3. The majority of sporadic cases are linked to methionine homozygosity at codon 129 of PRNP and the MM1 molecular subtype, though MM2-cortical and mixed types have also been described, sometimes correlating with a longer disease course 1,3,6."
"Most Heidenhain variant cases are sporadic, but rare genetic forms exist, often associated with PRNP mutations such as V210I 3. The majority of sporadic cases are linked to methionine homozygosity at codon 129 of PRNP and the MM1 molecular subtype, though MM2-cortical and mixed types have also been described, sometimes correlating with a longer disease course 1,3,6."
"The typical clinical presentation consists of early and often isolated onset of visual disturbances, such as blurred vision, visual field defects, visual hallucinations, and cortical blindness, before the development of cognitive decline or other neurological symptoms 1,5."