"There are various geographic trends for the subtypes of the disease 1. Overall, the disease is more common in areas where malaria is common and there may be some genetic advantage to the disease in such areas 2. African-Americans and other people of diasporic sub-Saharan African ancestry are also noted to have an increased occurrence. Most common forms of the disease are not known to tend towards one sex or gender."
"There are many forms of disease. The most common forms are EL1, EL2, EL3, and EL4 which each results from a different genetic mutation. The common end result of all genetic mutations that are pathogenic is that there is change in the cell membranes of erythrocytes; in the cases of EL1, EL2, and EL3 via a spectrin mutation 2. The diseases have a carrier state."
"There are no specific radiographic manifestations of hereditary elliptocytosis that distinguish it from other haemolytic anaemias. Some patients will present without radiologic findings however in some cases splenomegaly and cholelithiasis will be detected."
"While some patients may be asymptomatic or have minimal symptoms, the condition can cause anaemia, jaundice, splenomegaly and gallstones 3."
"There are many forms of disease. The most common forms are EL1, EL2, EL3, and EL4 which each results from a different genetic mutation. The common end result of all genetic mutations that are pathogenic is that there is change in the cell membranes of erythrocytes; in the cases of EL1, EL2, and EL3 via a spectrin mutation 2. The diseases have a carrier state."