"myxoid: loose basophilic or myxoid matrix"
"lipoma-like: containing more univacuolated white fat cells"
"spindle cell: resembling spindle cell lipoma"
"T1: hypointense to subcutaneous fat and hyperintense to muscle"
"T2: usually hypointense to subcutaneous fat"
"STIR/T2FS/IMFS: incomplete fat suppression"
"T1 C+ (Gd): diffuse enhancement"
"On CT, hibernomas are well-circumscribed and may have a peripheral soft tissue attenuation capsule. Their attenuation varies between that of fat and skeletal muscle 8."
"Hibernomas occur in a wide age range (from 2-75 years) 2,3, but are most often found in young adults between the ages of 20 and 40 and are slightly more common in males 2,3. They make up for about 1% of all adipocytic tumours"
"Hibernomas are typically fatty, hypervascular lesions that are grossly similar to a lipoma. They are well-defined, encapsulated, and mobile masses. Their colour varies from yellow-tan to red-brown, depending on the amount of intracellular lipid 2,3. The diameter usually ranges from 5-10 cm, but they may reach up to 20 cm or more 2,3, particularly in the retroperitoneum."
"typical or classical (most common):"
"T2: usually hypointense to subcutaneous fat"
"Immunohistochemistry displays reactivity of S100 in a majority of cases 3,4. CD34 will be positive in hibernomas with spindle cell morphology 3,4. They also express the brown fat marker gene UCP1 2."
"Cytogenic abnormalities of hibernomas are 11q13 translocations affecting the tumour suppressor genes MEN1 and AIP 2,4. Those rearrangements can aid in the diagnosis and the differentiation of hibernoma over other differentials such as liposarcoma 7."
Expected headings
"Associations"
"Signal characteristics"
"There is a causative connection to multiple endocrine neoplasia type 1 2."
"There is only partial or incomplete signal loss on fat suppression sequences due to the heterogeneous content of the mass and relatively decreased amount of lipid compared with adipose tissue 1,8."
"History and etymology"