"Second stage: meningoencephalitic stage "
"Human African trypanosomiasis (HAT), also known as African sleeping sickness, is an illness caused by one of two parasitic zoonoses: Trypanosoma brucei gambiense or Trypanosoma brucei rhodesiense 8."
"Human African trypanosomiasis is a disease endemic to sub-Saharan Africa. Within this region, the disease is harboured mainly in rural areas 1, where access to medical imaging is often non-existent. Trypanosoma brucei gambiense accounts for the vast majority of reported cases of human African trypanosomiasis. The incidence and prevalence have varied widely over the last two centuries. Under 3,000 cases were reported in 2016, and the incidence is declining 2."
"Symptoms of both subspecies of Trypanosoma brucei are similar, however the time course of symptoms is different."
"Trypanosoma brucei rhodesiense follows an acute time course, progressing to second-stage of disease within a few weeks, and then to death in 6 months if not treated. Whereas Trypanosoma brucei gambiense follows a chronic course, with a mean disease duration of 3 years 7.8."
"Trypanosoma brucei rhodesiens: submandibular, axillary, inguinal"
"Trypanosoma brucei gambiens: posterior triangle of the neck (Winterbottom’s sign)"
"trypanosomal chancres (more common in Trypanosoma brucei rhodesiense)"
"facial oedema (more common in Trypanosoma brucei gambiens)"
"Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense are transmitted by certain species of the tsetse fly, although other transmission routes such as via blood transfusion and congenital/vertical transmission are much rarer 3."
"Trypanosoma brucei gambiense:"
"Trypanosoma brucei rhodesiense:"
"first stage: WBC count ≤5 cells/μL and no trypanosomes"
"second stage: WBC count >5 cells/μL or the presence of trypanosomes"
"Trypanosoma brucei rhodesiens: submandibular, axillary, inguinal"
"Trypanosoma brucei gambiense:"
"Trypanosoma brucei rhodesiense:"
Expected headings
"First stage: haemolytic stage"
"Second stage: meningoencephalitic stage "