"definite:"
"probable:"
"possible:"
"grade 1: abnormal biomarkers or electrocardiogram"
"grade 2: mild clinical symptoms with abnormal biomarkers or ECG"
"grade 3:"
"grade 4: life-threatening disease with appropriate findings from the lower grades"
"Histopathologic features of immune checkpoint inhibitor-associated myocarditis include the following 7:"
Expected headings
"Classification"
"Echocardiography"
"MRI"
"There is a spectrum of clinical findings in the setting of immune checkpoint inhibitor-associated myocarditis, ranging from mild to severe disease. Correspondingly, clinical symptoms can vary from asymptomatic patients with abnormal cardiac biomarkers, to life-threatening conditions including heart failure, ventricular tachycardia, high-grade atrioventricular block or cardiogenic shock."
"Immunohistochemistry stains are usually positive for CD163, CD3, CD8, Granzyme B, PD1 and PD-L1 7."
"Cardiac MRI involves the Lake Louise criteria for the diagnosis of myocardial inflammation 2,7-9, which include two main criteria, myocardial oedema and myocardial injury as well as two supportive criteria, pericarditis and left ventricular dysfunction, with the main criteria supporting the diagnosis with high specificity if both are found, but also if only one can be found in the correct clinical setting or if supportive criteria are present 2,8-10."
"Cardiac MRI involves the Lake Louise criteria for the diagnosis of myocardial inflammation 2,7-9, which include two main criteria, myocardial oedema and myocardial injury as well as two supportive criteria, pericarditis and left ventricular dysfunction, with the main criteria supporting the diagnosis with high specificity if both are found, but also if only one can be found in the correct clinical setting or if supportive criteria are present 2,8-10."
"History and etymology"