"gastrointestinal stromal tumour (GIST): a heterogeneous family of submucosal tumours derived from interstitial cells of Cajal or common progenitor cells"
"the oncogenic mutations (80% c-KIT and 20% PDGFRA genes) produce abnormal receptor tyrosine kinase proteins that are always activated, leading to uncontrolled cell proliferation"
"the oncogenic mutations (80% c-KIT and 20% PDGFRA genes) produce abnormal receptor tyrosine kinase proteins that are always activated, leading to uncontrolled cell proliferation"
"extra-gastrointestinal GISTs arise from interstitial cells of Cajal in other organs"
"One cell type has an ancillary neural function as a gastrointestinal pacemaker, generating electrical slow waves that drive rhythmic smooth muscle contraction; peristalsis for propulsion and segmentation for mixing. Failure of this network causes gastroparesis and intestinal pseudo-obstruction."