Login
Toggle sidebar

Lint: langerhans-cell-histiocytosis-cns-manifestations

Strong
warning

"this is known as neurodegenerative Langerhans cell histiocytosis (ND-LCH)"

Line 10:29 · Generally, don't use bold in text: '<strong>neurodegenerative Langerhans cell histiocytosis (ND-LCH)</strong>'
Acronyms
warning

"GFAP: elevated"

Line 23:11 · 'GFAP' has no definition. Spell it out if it's unfamiliar to the audience.
Emphasis
warning

"Treatment is complex, but often involves prednisolone and chemotherapy 4. However this treatment is not effective in improving the diabetes insipidus or neurodegenerative symptoms 1,7,8. Hence, many patients additionally require desmopressin for diabetes insipidus 1. Treatment of neurodegeneration in LCH may include immunochemotherapy (e.g. BRAF V600E inhibitor therapy) 7-9."

Line 36:394 · Italics should be used only in exceptional circumstances: '<em>BRAF V600E</em>'
Headings Valid
warning

Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Diabetes insipidus"

Line 29:1 · "Diabetes insipidus" is not a recognised heading for this article type.

"Neurodegenerative changes"

Line 31:1 · "Neurodegenerative changes" is not a recognised heading for this article type.

"Mass lesions"

Line 33:1 · "Mass lesions" is not a recognised heading for this article type.
There Is
suggestion

"There are generally three distinct clinical presentations that may or may not all be present in any given patient:"

Line 5:4 · Don't start a sentence with 'There are'.

"There is proliferation of CD1a and CD207 Langerhans cells with an abundance of eosinophils, lymphocytes and neutrophils, typically affecting the hypothalamic-pituitary axis, cerebellum, and basal ganglia, accounting for the clinical presentation and radiographic features 2,4."

Line 16:4 · Don't start a sentence with 'There is'.
Oxford Comma
suggestion

"There is proliferation of CD1a and CD207 Langerhans cells with an abundance of eosinophils, lymphocytes and neutrophils, typically affecting the hypothalamic-pituitary axis, cerebellum, and basal ganglia, accounting for the clinical presentation and radiographic features 2,4."

Line 16:90 · Use the Oxford comma in 'eosinophils, lymphocytes and neutrophils'.
Commas
suggestion

"There is proliferation of CD1a and CD207 Langerhans cells with an abundance of eosinophils, lymphocytes and neutrophils, typically affecting the hypothalamic-pituitary axis, cerebellum, and basal ganglia, accounting for the clinical presentation and radiographic features 2,4."

Line 16:101 · More than 5 commas in a single sentence might make it more difficult to read.

"Mass lesions are the least common CNS manifestation of LCH 2,3. Masses have a variable MR appearance and can arise from the meninges (especially the dura mater), pineal gland, choroid plexus, hypothalamus, ependyma, or can rarely be intraparenchymal 2,3. These lesions, depending on size and location, may cause obstructive hydrocephalus 2,3."

Line 34:189 · More than 5 commas in a single sentence might make it more difficult to read.