"The various LGMD are diverse in ethnic and geographic distribution. Several types of LGMD, e.g. LGMD2L, are understood to have some level of male predominance 1,2,3."
"The various LGMD are diverse in ethnic and geographic distribution. Several types of LGMD, e.g. LGMD2L, are understood to have some level of male predominance 1,2,3."
"Various limb girdle dystrophies show distinct patterns of specific muscle involvement 5, thus lower limb imaging can be useful in diagnosing the specific LGMD. Mercuri scores for CTs and MRIs or Heckmatt scores for US are a tools that can be applied to grade various muscles in appearance, however it is the pattern of muscle involvement (which particular muscles are spared versus affected) and not always the extent of it that is useful in terms of diagnosis."
"Duchenne muscular dystrophy"
"Becker muscular dystrophy"
"MRI, CT and ultrasound will all eventually show evidence of muscle degeneration and fatty infiltration, however MRI is the preferred modality for diagnosis of the diseases."
"The management of these entities should be multidisciplinary and involve care from cardiology if cardiomyopathy develops. There is active research into gene therapy 5. Prognosis for these entities is extremely variable."