"T4b: tumour invades beyond adjacent structures including:"
"cNX: regional lymph nodes cannot be assessed"
"cN0: no regional lymph node metastasis"
"cN1: metastasis in 1–3 lymph node(s) without cENE/iENE"
"cN2: metastasis in more than 3 lymph nodes or any lymph node with cENE/iENE"
"pNX: regional lymph nodes cannot be assessed"
"pN0: no regional lymph node metastasis"
"pN1: metastasis in 1–3 lymph node without definitive pathological extranodal extension (pENE)"
"pN2: metastasis in >3 lymph nodes or metastasis in any lymph node with pENE"
"cN1: metastasis in 1–3 lymph node(s) without cENE/iENE"
"pN1: metastasis in 1–3 lymph node without definitive pathological extranodal extension (pENE)"
"cN1: metastasis in 1–3 lymph node(s) without cENE/iENE"
"Salivary gland cancer staging refers to TNM staging of malignant tumours of the salivary glands (parotid, submandibular, sublingual and minor salivary glands), the most common tumours being mucoepidermoid, adenoid cystic and acinic cell carcinoma, as well as numerous rarer tumour types. From the 9th edition onwards, tumours arising from minor salivary glands are also included in this staging system as opposed to the staging system based on their anatomical site of origin."
"The following article reflects the 9th version published by the Union for International Cancer Control (UICC) and American Joint Committee on Cancer (AJCC) in 2025 1,2."
"The following article reflects the 9th version published by the Union for International Cancer Control (UICC) and American Joint Committee on Cancer (AJCC) in 2025 1,2."
"TX: primary tumour cannot be assessed"
"The terms pM0 and MX are not valid TNM categories. The following categories may be used, either in the clinical classification (c) for patients with cancer identified before treatment and/or in the pathological classification (p) for patients for whom surgery is the first definitive therapy:"
"Primary tumour (T)"
"Regional lymph node (N)"
"Clinical (cN) criteria"
"Pathological (pN) criteria"
"Distant metastases (M)"
"Tis: carcinoma in situ"
"T4a: tumour invades immediately adjacent structures including:"
"T4b: tumour invades beyond adjacent structures including:"
"Stage 0"
"Tis, N0, M0"
"Stage IIIA"
"Stage IIIB"
"**Destruction of intrinsic sinus bones is not considered bone invasion for skull base tumours. Erosion of cortical bone is not considered bone invasion; a minor salivary gland tumour arising within the bone is not considered bone invasion."
"**Destruction of intrinsic sinus bones is not considered bone invasion for skull base tumours. Erosion of cortical bone is not considered bone invasion; a minor salivary gland tumour arising within the bone is not considered bone invasion."
"**Destruction of intrinsic sinus bones is not considered bone invasion for skull base tumours. Erosion of cortical bone is not considered bone invasion; a minor salivary gland tumour arising within the bone is not considered bone invasion."
Expected headings
"Primary tumour (T)"
"Regional lymph node (N)"
"Clinical (cN) criteria"
"Pathological (pN) criteria"
"Distant metastases (M)"
"Stage groups"
"Changes since prior versions"
"Salivary gland cancer staging refers to TNM staging of malignant tumours of the salivary glands (parotid, submandibular, sublingual and minor salivary glands), the most common tumours being mucoepidermoid, adenoid cystic and acinic cell carcinoma, as well as numerous rarer tumour types. From the 9th edition onwards, tumours arising from minor salivary glands are also included in this staging system as opposed to the staging system based on their anatomical site of origin."
"There have been several changes between the 8th and 9th editions. Minor salivary gland tumours are now included in this staging system as opposed to their anatomical site of origin, and thus the section name has been changed from 'major salivary gland carcinoma' to 'salivary gland carcinoma'. The T stages for T3, T4a and T4b have new criteria. The nodal staging no longer follows the rest of the head and neck systems and has been simplified. The stages have also been simplified."
"**Destruction of intrinsic sinus bones is not considered bone invasion for skull base tumours. Erosion of cortical bone is not considered bone invasion; a minor salivary gland tumour arising within the bone is not considered bone invasion."