"The incidence of CNS metastatic disease in group 3 tumours at diagnosis is common, found in 30% of all cases, and is even more frequent in infants (47%) 1,2. This often is the case even when the tumour is small, which can be a clue to the diagnosis pre-operatively 4."
"The nomenclature and classification of medulloblastomas are rapidly evolving. In the 5th edition (2021) of the WHO classification of CNS tumours, group 3 and group 4 medulloblastomas are grouped together under non-WNT/non-SHH tumours, which is in turn divided into 8 subgroups 5."
"The nomenclature and classification of medulloblastomas are rapidly evolving. In the 5th edition (2021) of the WHO classification of CNS tumours, group 3 and group 4 medulloblastomas are grouped together under non-WNT/non-SHH tumours, which is in turn divided into 8 subgroups 5."
"Group 3 tumours have the worse prognosis compared to other subtypes of medulloblastoma, similar to group 4 tumours, but significantly worse than SHH and WNT subtypes 1,2:"
"Group 3 tumours have the worse prognosis compared to other subtypes of medulloblastoma, similar to group 4 tumours, but significantly worse than SHH and WNT subtypes 1,2:"
"The radiographic features of group 3 tumours are similar to group 4 tumours (which we typically associate with medulloblastomas; midline masses arising from the vermis). Unlike group 4 tumours, group 3 tumours tend to be less well defined but have more prominent enhancement 3."