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Lint: myalgic-encephalomyelitischronic-fatigue-syndrome

Acronyms
warning

"In 1934, following the first reports of this mysterious condition it was named neuromyasthenia. In 1959, it was renamed benign myalgic encephalomyelitis as it began to be thought of as an inflammatory disorder. The Centre for Disease Control and Prevention (CDC) in the US in 1987 created a working group, which after much discussion about its nomenclature settled upon the term "chronic fatigue syndrome". However myalgic encephalomyelitis was internationally in such widespread use by this point, that the condition became known as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), its preferred monicker 4."

Line 3:274 · 'US' has no definition. Spell it out if it's unfamiliar to the audience.

"GI symptoms: abdominal discomfort, nausea, loss of appetite"

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Oxford Comma
suggestion

"ME/CFS is seen in all ages, ethnicities and socioeconomic strata. There are two spikes in time of onset, in the second and fourth decades. In teenagers, females predominate 3-4:1. It is thought that as many as 91% of adult patients have not been diagnosed according to accepted criteria 1."

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"A cardinal feature of myalgic encephalomyelitis/chronic fatigue syndrome is an aggravation of symptoms by even the most minor of physical and/or mental efforts. These symptoms then often may remain for hours, days or weeks despite adequate rest."

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There Is
suggestion

"ME/CFS is seen in all ages, ethnicities and socioeconomic strata. There are two spikes in time of onset, in the second and fourth decades. In teenagers, females predominate 3-4:1. It is thought that as many as 91% of adult patients have not been diagnosed according to accepted criteria 1."

Line 6:70 · Don't start a sentence with 'There are'.