"T1: three-dimensional T1 images to look for brain morphology changes, and atrophy. T1-weighted images are useful to look for metallic deposits such as copper and iron molecular complexes that appear hyperintense 4"
"T2/FLAIR: evaluate white matter changes, gliosis, and cavitations 4"
"T2*/SWI: microscopic iron depositions especially hypointensities in the bilateral global pallidus 4"
"Treatment and prognosis "
"PLA2G6-associated neurodegeneration (PLAN)"
"accounts for ~6-10% of NIBA"
"accounts of 1-2% of NIBA"
Expected headings
"Treatment and prognosis "
"Neurodegeneration with brain iron accumulation (NBIA), is a heterogeneous group of rare genetic disorders characterised by accumulation of iron in the basal ganglia, which results in variable neurological disorders including extrapyramidal symptoms, neuropsychiatric and visual symptoms."