"term birth:"
"3-4 months:"
"6 months:"
"12 months:"
"18 months:"
"24 months:"
"term birth: "
"3-4 months:"
"6 months:"
"12 months:"
"18 months:"
"24 months:"
"centrum semiovale: T1 at 2-4 months, T2 at 7-11 months"
"occipital white matter:"
"mid-frontal white matter:"
"anterior frontal white matter:"
"proton density: "
"unsurprisingly follows the same pattern as T2 but lags behind somewhat. The exception is deep cerebral white matter, which begins as heterogeneously hypointense during the first few months of life."
"deep: T1 at 3-5 months, T2 at 9-14 months"
"subcortical: T1 at 4-7 months, T2 at 11-15 months"
"deep: T1 at 3-6 months, T2 at 11-16 months"
"subcortical: T1 at 7-11 months, T2 at 14-18 months"
"deep: T1 at 5-8 months, T2 at 12-18 months"
"subcortical: T1 at 10-15 months, T2 at 24-30 months"
"most sensitive sequence in children between the age of 1 and 2 demonstrating a gradual shift from hyper- to hypo-intense relative to grey matter"
"differentiation between terminal zones and PVL requires detection of normally myelinated white matter between the patchy hyperintense T2 signal and the lateral ventricle"
"MR spectroscopy demonstrates elevated myoinositol and choline in neonates which gradually declines. Myoinositol decreases to adult values by end of first year and choline by 2-3 years. NAA increases with myelination (in the first year of life)."
Expected headings
"T1 myelination milestones"
"T2 myelination milestones"
"White matter myelination by location"
"After normal myelination in utero, myelination of the neonatal brain is far from complete. The first myelination is seen as early as the 16th week of gestation, in the column of Burdach, but only really takes off from the 24th week 1. It does not reach maturity until 2 years or so. It correlates very closely to developmental milestones 3. The progression of myelination is predictable and abides by a few simple general rules; myelination progresses from:"