"Oral cavity carcinoma staging refers to TNM staging of carcinomas involving the oral cavity including the mucosal surfaces of the lips. Carcinoma of the vermillion border of the lip should be staging under the 'carcinoma of skin of the head and neck region'. The vast majority of applicable cases are squamous cell carcinomas, but other epithelial and minor salivary gland cancers are also included."
"The following article reflects the 9th version published by Union for International Cancer Control (UICC) in 2025, which is identical to the 8th version published by the American Joint Committee on Cancer (AJCC) in 2017 1,2."
"The following article reflects the 9th version published by Union for International Cancer Control (UICC) in 2025, which is identical to the 8th version published by the American Joint Committee on Cancer (AJCC) in 2017 1,2."
"TX: primary tumour cannot be assessed"
"The terms pM0 and MX are not valid TNM categories. The following categories may be used:"
"Primary tumour (T)"
"Regional lymph node (N)"
"Distant metastases (M)"
"Tis: carcinoma in situ"
"T4a: moderately advanced local disease:"
"T4b: very advanced local disease:"
"Tis, N0, M0"
"T4a, [N0, N1], M0"
"T4b, [Any N], M0"
"The 8th version places importance on depth of invasion for primary tumour staging 4, which is correlated with, but not the same as, tumour thickness assessed radiologically 5. Pathologically, the depth of invasion is defined relative to the horizon of the nearest normal mucosal surface 6. Thus, depth of invasion is greater than tumour thickness when the tumour is ulcerative, and depth of invasion is less than tumour thickness when the tumour is exophytic. Emerging research has demonstrated a high correlation between the radiologic depth of invasion measured on intraoperative ultrasound and the histopathologic depth of invasion 7."
Expected headings
"Primary tumour (T)"
"Regional lymph node (N)"
"Distant metastases (M)"
"Stage groups"
"Changes since prior versions"
"tumour invades adjacent structures (e.g. through cortical bone of mandible or maxilla*, into the maxillary sinus, into the skin of face**)"
"The dry vermilion lip has been removed from the definition of oral cavity; tumours affecting that site are instead classified with cutaneous carcinoma of the head and neck. Moreover, the distinction between lip and oral cavity for T4a criteria has been removed."