"T1: lack of myelination, often seen as low T1 signal regions typically involving internal capsule, proximal corona radiata and the optic radiation"
"T2: near complete absence of expected low signal in the supratentorial region"
"History and etymology "
"Named after Friedrich Christoph Pelizaeus (1851-1942), a German neurologist, and Ludwig Merzbacher (1875-1942), an Italian neuropathologist and psychiatrist."
"Salla disease (SLC17A5 gene at 6q14-q15)."
"Pelizaeus-Merzbacher disease is the result of abnormalities of the proteolipidprotein (PLP1) gene locus at Xq22. This can be either a mutation, deletion or duplication (most common) 4."
"affected areas often show a reduction in the NAA peak 4"
"Named after Friedrich Christoph Pelizaeus (1851-1942), a German neurologist, and Ludwig Merzbacher (1875-1942), an Italian neuropathologist and psychiatrist."
"Named after Friedrich Christoph Pelizaeus (1851-1942), a German neurologist, and Ludwig Merzbacher (1875-1942), an Italian neuropathologist and psychiatrist."
Expected headings
"Subtypes"
"History and etymology "
"Pelizaeus-Merzbacher disease is the result of abnormalities of the proteolipidprotein (PLP1) gene locus at Xq22. This can be either a mutation, deletion or duplication (most common) 4."