"The histological grade of the primary lymphoma influences the risk of developing secondary CNS lymphoma: if the primary lymphoma is indolent, aggressive, or highly aggressive, the risk of developing SCNSL 2 is 3%, 9%, and 27%, respectively 2."
"Secondary CNS lymphoma can manifest with a new-onset headache, cranial nerve palsies (especially the III, IV, VI, and VII nerves), changes in mental status, and even coma and seizures 2."
"Contrast-enhanced MRI is the modality of choice. Imaging features of leptomeningeal secondary CNS lymphoma include leptomeningeal, dural, subependymal and cranial nerve enhancement. Communicating hydrocephalus may be present."