"Pseudoprogression can be considered if, after beginning targeted therapy, the early follow-up study shows growth of the target lesion(s) and, occasionally, even appearance of new lesions. In some cases, transformation of the lesions to larger ground glass opacities may occur. This is mostly, but not universally, coupled with clinical stability or improvement. Thus, the diagnosis of radiologic pseudoprogression often warrants knowledge of the clinical status of the patient. Upon subsequent continued therapy patients having radiologic pseudoprogression will show stability or regression, while those with true progression will show further lesion growth and development of new lesions 1."
"Practical points "
"Radiologic pseudoprogression is typically not accompanied by specific symptoms, with patients usually appearing clinically stable or even improving 2. Unfortunately, it has been also shown that a small subset of patients with subsequently confirmed pseudoprogression will demonstrate worsening of symptoms as well, a phenomenon termed symptomatic pseudoprogression 5."
Expected headings
"Practical points "