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Lint: tumour-necrosis-factor-tnf

tumour-necrosis-factor-tnf
Headings Spacing
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"TNF-alpha and its receptors "

Line 22:1 · Never put spaces at either end of headings.
Acronyms
warning

"Tumour necrosis factor, (TNF), typically represented by TNF-alpha (TNF-α), is a pleiotropic cytokine that acts on various tissues and cell types and plays a critical role in regulating the cell life cycle. It exerts a range of context-dependent immune-modulating effects across a wide variety of tissues and cell types, hence the term pleiotropic 3:"

Line 1:54 · 'TNF' has no definition. Spell it out if it's unfamiliar to the audience.

"Tumour necrosis factor, (TNF), typically represented by TNF-alpha (TNF-α), is a pleiotropic cytokine that acts on various tissues and cell types and plays a critical role in regulating the cell life cycle. It exerts a range of context-dependent immune-modulating effects across a wide variety of tissues and cell types, hence the term pleiotropic 3:"

Line 1:94 · 'TNF' has no definition. Spell it out if it's unfamiliar to the audience.

"Tumour necrosis factor, (TNF), typically represented by TNF-alpha (TNF-α), is a pleiotropic cytokine that acts on various tissues and cell types and plays a critical role in regulating the cell life cycle. It exerts a range of context-dependent immune-modulating effects across a wide variety of tissues and cell types, hence the term pleiotropic 3:"

Line 1:113 · 'TNF' has no definition. Spell it out if it's unfamiliar to the audience.

"macrophages: TNF-α is produced by macrophages and acts upon them to amplify inflammatory responses"

Line 3:21 · 'TNF' has no definition. Spell it out if it's unfamiliar to the audience.

"TNF inhibitors such as infliximab, adalimumab and etanercept are biologics, and are widely used to modify disease."

Line 21:4 · 'TNF' has no definition. Spell it out if it's unfamiliar to the audience.

"TNF-alpha and its receptors"

Line 22:5 · 'TNF' has no definition. Spell it out if it's unfamiliar to the audience.

"TNF-alpha exerts its effects through two distinct receptors that underpin its functional ambivalence: TNFR1 (p55), which triggers intracellular "death domains" to mediate apoptosis, and TNFR2 (p75), which is involved in cell survival, proliferation, and immune modulation. The resulting biological response is context-dependent, determined by the ligand concentration and the specific receptor profile expressed by the target cell at any given time 4-7."

Line 23:4 · 'TNF' has no definition. Spell it out if it's unfamiliar to the audience.

"TNF-α was identified as a serum factor capable of inducing haemorrhagic necrosis in tumour cells by Lloyd Old and colleagues in the 1970s 1,2."

Line 25:4 · 'TNF' has no definition. Spell it out if it's unfamiliar to the audience.
Colons
warning

"TNF-alpha exerts its effects through two distinct receptors that underpin its functional ambivalence: TNFR1 (p55), which triggers intracellular "death domains" to mediate apoptosis, and TNFR2 (p75), which is involved in cell survival, proliferation, and immune modulation. The resulting biological response is context-dependent, determined by the ligand concentration and the specific receptor profile expressed by the target cell at any given time 4-7."

Line 23:104 · The first word after a colon should almost always be lowercase. In this case, it's not: ': TNFR1 (p55'.
Headings Valid
warning

Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"TNF-alpha and its receptors "

Line 22:1 · "TNF-alpha and its receptors " is not a recognised heading for this article type.

"Etymology"

Line 24:1 · "Etymology" is not a recognised heading for this article type.
Oxford Comma
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"lymphocytes: modulates T and B cell proliferation, survival and activation"

Line 5:44 · Use the Oxford comma in 'proliferation, survival and activation'.

"TNF inhibitors such as infliximab, adalimumab and etanercept are biologics, and are widely used to modify disease."

Line 21:27 · Use the Oxford comma in 'infliximab, adalimumab and etanercept'.
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