"Although Bhim Sen Singhal (1933-), an Indian neurologist, initially described a megalencephalic leukodystrophy series of cases in 1991 5,6, it is sometimes named after Marjo S van der Knaap (1958-), a Dutch paediatric neurologist, who detailed another series with clinical and radiological features in 1995 4,7."
"Although Bhim Sen Singhal (1933-), an Indian neurologist, initially described a megalencephalic leukodystrophy series of cases in 1991 5,6, it is sometimes named after Marjo S van der Knaap (1958-), a Dutch paediatric neurologist, who detailed another series with clinical and radiological features in 1995 4,7."
"Patients typically present with megalencephaly during the first year of life associated with mild motor developmental delay and seizures 5. There is also a gradual onset of ataxia, spasticity, dysarthria, and sometimes extrapyramidal findings. Mild mental deterioration can be observed late in life."
"diffuse, bilateral and symmetric T2-weighted hyperintensity and T1-weighted hypointensity in the cerebral white matter, giving a characteristic 'swollen' appearance"
"Although Bhim Sen Singhal (1933-), an Indian neurologist, initially described a megalencephalic leukodystrophy series of cases in 1991 5,6, it is sometimes named after Marjo S van der Knaap (1958-), a Dutch paediatric neurologist, who detailed another series with clinical and radiological features in 1995 4,7."