"platelet count ≤100 x 109/L"
"This condition was first described in 1944 by Swedish haem-oncologist Jan Gosta Waldenström (1906-1996) 1,12."
"Waldenström macroglobulinaemia is classified as a subtype of lymphoplasmacytic lymphoma with any level of an IgM paraprotein; these two conditions are not synonymous 10."
"Asymptomatic patients who fulfil the diagnosis of Waldenström macroglobulinaemia but are asymptomatic have smouldering macroglobulinaemia and do not require treatment 14."
"IgM monoclonal gammopathy"
Expected headings
"Treatment"
"Prognosis"
"Complications"
"Waldenström macroglobulinaemia is classified as a subtype of lymphoplasmacytic lymphoma with any level of an IgM paraprotein; these two conditions are not synonymous 10."
"mild-to-moderate splenomegaly (~15%; range 10-20%) 13,14"
"musculoskeletal: osteopenia, marrow space widening, endosteal erosions, lytic bone lesions (-15%; range 8-24%) 13"
"The pathogenesis is poorly understood but may resemble that of chronic lymphocytic leukaemia. Clonal proliferation of functionally impaired B-cells occurs, as well as infiltration of various tissues (predominantly bone marrow, spleen, and lymph nodes). There is an overproduction of IgM, leading to hyperviscosity syndrome and resultant impaired microcirculation."
"lymphadenopathy (~15%): in particular abdominal, pelvic, inguinal and axillary nodes 13,14"
"rituximab can be used for systemic treatment but is often used with other agents (e.g. cyclophosphamide/dexamathasone)"