"Although it has been reported to be a specific sign of severe Clostridioides difficile colitis, it has also been described in other forms of non-specific, ischaemic, and non-Clostridioides difficile infective colitides 1."
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Italics should be used only in exceptional circumstances: '<em>Clostridioides difficile </em>colitis</a>, it has also been described in other forms of non-specific, <a>ischaemic</a>, and non-<em>Clostridioides difficile</em>'