"ALERD predominantly affects children, with a mean age of onset around 3-4 years, with a slight male predominance (60–65% of cases). The exact incidence remains undetermined; however, case series indicate that ALERD is diagnosed in ~15% of children presenting with non-traumatic encephalopathy 1,4,5. Most reported cases are from Asia and India 1,4,5."
"Acute leukoencephalopathy with restricted diffusion (ALERD) is a recently recognised clinicoradiological spectrum of disease with clinical features of leukoencephalopathy and associated imaging findings where diffusion restriction is the dominant finding 1. It is sometimes considered a subtype of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) 7 and, as such, forms part of the Infection Triggered Encephalopathy Syndromes group 7."
"acute encephalopathy with biphasic seizures and late reduced diffusion (AESD)"
"ALERD predominantly affects children, with a mean age of onset around 3-4 years, with a slight male predominance (60–65% of cases). The exact incidence remains undetermined; however, case series indicate that ALERD is diagnosed in ~15% of children presenting with non-traumatic encephalopathy 1,4,5. Most reported cases are from Asia and India 1,4,5."
"Routine laboratory and CSF findings are often unremarkable or non-specific; mainly used to rule out other causes. Diagnosis is clinico-radiological based on the combination of symptoms and characteristic MRI findings 3."