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Lint: alpha-antitrypsin-deficiency

alpha-antitrypsin-deficiency
Number Comparisons
error

"if CRP is > 8 mg/L and AAT ≥1.1 g/L, re-testing when CRP is normal or proceeding to genotyping is recommended 30"

Line 25:18 · There should never be a space after less and greater than signs.
Acronyms
warning

"Alpha-1-antitrypsin (AAT) deficiency is an autosomal codominant genetic disorder that increases the risk of respiratory and hepatic disease."

Line 1:33 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"The estimated prevalence is 1 in ~2000 (range 2000-4000) individuals with European ancestry 30 and is considered the most common genetic mutation in the White population 28. It is reported to be uncommon in people of Asian descent ref. Approximately 90% of individuals with severe AAT deficiency remain undiagnosed 28."

Line 3:318 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"The classic presentation of the AAT deficiency is dyspnoea in the 4th to 5th decades 29."

Line 5:36 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"AAT is a protein that prevents enzymes such as elastase from degrading normal host tissue. It is mostly (90%) secreted by hepatocytes into the blood circulation 30."

Line 8:4 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"AAT is an acute phase reactant, rising 2-3x during an acute inflammatory response, which could mask a moderate-to-severe AAT deficiency 30"

Line 24:8 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"AAT is an acute phase reactant, rising 2-3x during an acute inflammatory response, which could mask a moderate-to-severe AAT deficiency 30"

Line 24:129 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"if CRP is > 8 mg/L and AAT ≥1.1 g/L, re-testing when CRP is normal or proceeding to genotyping is recommended 30"

Line 25:31 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"PiSS: moderate-to-severe AAT deficiency 30"

Line 38:33 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"PiZZ: severe AAT deficiency at high risk of developing emphysema 26"

Line 39:21 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"PiMZ: mild AAT deficiency; at some risk of developing lung and liver disease if other risk factors are present 29"

Line 46:19 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"PiSZ: moderate-to-severe AAT deficiency 29"

Line 47:33 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"Many conditions are associated with AAT deficiency:"

Line 52:40 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.

"chronic obstructive pulmonary disease (COPD): up to 2% of patients with COPD have severe AAT deficiency 30"

Line 54:104 · 'AAT' has no definition. Spell it out if it's unfamiliar to the audience.
List Caps
warning

"PiMM: normal individuals 26"

Line 37:8 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.

"PiSS: moderate-to-severe AAT deficiency 30"

Line 38:8 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.

"PiZZ: severe AAT deficiency at high risk of developing emphysema 26"

Line 39:8 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.

"PiMS: minimally or not clinically significant 30"

Line 45:8 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.

"PiMZ: mild AAT deficiency; at some risk of developing lung and liver disease if other risk factors are present 29"

Line 46:8 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.

"PiSZ: moderate-to-severe AAT deficiency 29"

Line 47:8 · In general, we don't start a list item with a capital letter. Exceptions are proper nouns.
Headings Valid
warning

Expected headings

  • H1 Terminology
  • H1 Usage
  • H1 Epidemiology
  • H2 Risk factors
  • H2 Associations
  • H1 Clinical presentation
  • H2 Complications
  • H1 Diagnosis
  • H2 Diagnostic criteria
  • H2 Diagnostic clues
  • H1 Pathology
  • H2 Aetiology
  • H2 Location
  • H2 Classification
  • H2 Macroscopic appearance
  • H2 Microscopic appearance
  • H2 Immunophenotype
  • H2 Markers
  • H2 Genetics
  • H1 Radiographic features
  • H2 Plain radiograph
  • H2 Mammography
  • H2 Antenatal ultrasound
  • H2 Transoesophageal echocardiography
  • H2 Ultrasound
  • H2 CT
  • H3 Dual-energy CT
  • H2 Angiography (DSA)
  • H2 MRI
  • H2 CT/MRI
  • H2 Nuclear medicine
  • H3 PET-CT
  • H3 PET-MRI
  • H1 Radiology report
  • H1 Treatment and prognosis
  • H2 Complications
  • H1 History and etymology
  • H1 Differential diagnosis
  • H2 Clinical differential diagnosis
  • H1 Practical points
  • H1 See also

"Associations"

Line 51:1 · "Associations" is under the wrong parent heading (found under "Pathology").

"Thoracic manifestations"

Line 64:1 · "Thoracic manifestations" is not a recognised heading for this article type.

"Plain radiograph and CT"

Line 65:1 · "Plain radiograph and CT" is not a recognised heading for this article type.

"Nuclear medicine"

Line 80:1 · "Nuclear medicine" should be H2, not H3.

"Abdominal manifestations"

Line 82:1 · "Abdominal manifestations" is not a recognised heading for this article type.

"Complications"

Line 90:1 · "Complications" is under the wrong parent heading (found under "Treatment and prognosis").
Semicolons
suggestion

";"

Line 17:38 · Use semicolons judiciously.

"PiMZ: mild AAT deficiency; at some risk of developing lung and liver disease if other risk factors are present 29"

Line 46:33 · Use semicolons judiciously.

"basal predominance, in contradistinction to centrilobular emphysema, which shows apical predominance; the two conditions can coexist in smokers"

Line 71:115 · Use semicolons judiciously.
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