"Symptoms of COPD include dyspnoea on exertion, wheezing, productive cough, pursed-lip breathing, and use of accessory respiratory muscles. Historically, patients with chronic bronchitis were termed "blue bloaters," while those with emphysema known as "pink puffers". In advanced cases, muscle wasting, asterixis, and peripheral oedema may be seen."
"stage I: mild, FEV1 > 80% of normal"
"stage II: moderate, FEV1 = 50-79% of normal"
"stage III: severe, FEV1 = 30-49% of normal"
"stage IV: very severe, FEV1"
"stage I: mild, FEV1 > 80% of normal"
"low QRS voltage"
"amplitude of QRS complexes"
"panacinar: homozygous AAT1 deficiency and uniformly destroys alveoli"
"Pulmonary function testing (PFT) reveals airflow obstruction, as evidenced by a decreased forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) ratio. Administration of bronchodilators has no effect, unlike the reversible obstruction seen in asthma."
"Pulmonary function testing (PFT) reveals airflow obstruction, as evidenced by a decreased forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) ratio. Administration of bronchodilators has no effect, unlike the reversible obstruction seen in asthma."
"The global initiative for chronic obstructive lung disease (GOLD) staging system is a commonly used severity staging system based on airflow limitation. According to this, there are four key stages with the latest revision at time of writing being in 2019 17:"
"stage I: mild, FEV1 > 80% of normal"
"stage II: moderate, FEV1 = 50-79% of normal"
"stage III: severe, FEV1 = 30-49% of normal"
"stage IV: very severe, FEV1"
"The FEV1:FVC ratio should be"
"The FEV1:FVC ratio should be"
"The GOLD staging system may be insensitive in early stages 12."
"Findings of chronic bronchitis on chest radiography are non-specific and include increased bronchovascular markings and cardiomegaly. Emphysema manifests as lung hyperinflation with flattened hemidiaphragms, a small heart, and possible bullous changes. On the lateral radiograph, a "barrel chest" with widened anterior-posterior diameter may be visualised. The "sabre-sheath trachea" sign refers to marked coronal narrowing of the intrathoracic trachea (frontal view) with concomitant sagittal widening (lateral view)."
Expected headings
"ECG"
"Severity classification"
"Clinical phenotypes"
"Chronic bronchitis"
"Emphysema"
"Complications"
"Lifestyle measures"
"Pharmacology"
"Surgery"
"There are however a number of other less common risk factors/aetiologies, each with their own demographics. They include:"
"industrial exposure (e.g. mining)"
"Pharmacological management is generally first-line. It involves the use of bronchodilators, corticosteroids, and other medications (e.g. methylxanthines, leukotriene receptor antagonists, phosphodiesterase type-4 inhibitors, omalizumab), as well as supplemental oxygen and pulmonary rehabilitation. Long-acting β2-agonist (LABA) and long-acting muscarinic antagonist (LAMA) combination therapies are considered the most effective strategy 16."