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Lint: anaplastic-large-cell-lymphoma-alkalk

anaplastic-large-cell-lymphoma-alkalk
Acronyms
warning

"ALK-positive anaplastic large-cell lymphoma"

Line 4:8 · 'ALK' has no definition. Spell it out if it's unfamiliar to the audience.

"ALK-negative anaplastic large-cell lymphoma"

Line 5:8 · 'ALK' has no definition. Spell it out if it's unfamiliar to the audience.

"ALK+ ALCL is most commonly encountered in children, adolescents and young adults (median age 30 years). It is rare, accounting for only 3% of adult non-hodgkin lymphomas 4."

Line 10:4 · 'ALK' has no definition. Spell it out if it's unfamiliar to the audience.

"In contrast, ALK- ALCL are typically encountered in older adults (median age 54 years)."

Line 11:17 · 'ALK' has no definition. Spell it out if it's unfamiliar to the audience.

"In the majority of ALK+ ALCL cases, lymph nodes are involved (90%), with extranodal involvement fairly commonly encountered, most commonly of skin, soft tissues, bone, and lung 4."

Line 15:23 · 'ALK' has no definition. Spell it out if it's unfamiliar to the audience.

"In contrast, ALK- ALCL cases are more commonly extranodal with approximately half of patients presenting with a single site of disease 5. Soft tissues, breast, liver, bone, mediastinum, and gastrointestinal tract are encountered 5."

Line 16:17 · 'ALK' has no definition. Spell it out if it's unfamiliar to the audience.

"Both ALK+ and ALK- ALCL are rare in the central nervous system, most commonly presenting as one or more masses of the supratentorial parenchyma. Involvement of the posterior fossa is less common. Spinal cord, meningeal or skull involvement is rare 3."

Line 17:9 · 'ALK' has no definition. Spell it out if it's unfamiliar to the audience.

"Both ALK+ and ALK- ALCL are rare in the central nervous system, most commonly presenting as one or more masses of the supratentorial parenchyma. Involvement of the posterior fossa is less common. Spinal cord, meningeal or skull involvement is rare 3."

Line 17:18 · 'ALK' has no definition. Spell it out if it's unfamiliar to the audience.

"ALK+ tumours demonstrate anaplastic lymphoma kinase (ALK) gene rearrangements, and are positive for EMA 3."

Line 23:114 · 'EMA' has no definition. Spell it out if it's unfamiliar to the audience.
Emphasis
warning

"DUSP22 rearrangement"

Line 28:8 · Italics should be used only in exceptional circumstances: '<em>DUSP22</em>'
Oxford Comma
suggestion

"ALK+ ALCL is most commonly encountered in children, adolescents and young adults (median age 30 years). It is rare, accounting for only 3% of adult non-hodgkin lymphomas 4."

Line 10:46 · Use the Oxford comma in 'children, adolescents and young'.

"Both ALK+ and ALK- ALCL are rare in the central nervous system, most commonly presenting as one or more masses of the supratentorial parenchyma. Involvement of the posterior fossa is less common. Spinal cord, meningeal or skull involvement is rare 3."

Line 17:207 · Use the Oxford comma in 'cord, meningeal or skull'.
Commas
suggestion

"In the majority of ALK+ ALCL cases, lymph nodes are involved (90%), with extranodal involvement fairly commonly encountered, most commonly of skin, soft tissues, bone, and lung 4."

Line 15:38 · More than 5 commas in a single sentence might make it more difficult to read.
Semicolons
suggestion

"Treatment is primarily with chemotherapy; allogeneic transplant is reserved for cases that do not respond 4."

Line 25:44 · Use semicolons judiciously.
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