"The causes of particle accumulation include implant interface wear, microscopic motion occurring in response to corrosion, oxidative reactions, and minor pathogen contamination. The initial response to particulate debris can include a subtle inflammatory response, which becomes more pronounced as osteolysis progresses. This inflammatory environment provokes a cellular response that is characterised by elevated levels of secreted factors such as TNF, RANKL, IL-6, IL-1, and IL-11."
"The causes of particle accumulation include implant interface wear, microscopic motion occurring in response to corrosion, oxidative reactions, and minor pathogen contamination. The initial response to particulate debris can include a subtle inflammatory response, which becomes more pronounced as osteolysis progresses. This inflammatory environment provokes a cellular response that is characterised by elevated levels of secreted factors such as TNF, RANKL, IL-6, IL-1, and IL-11."
"DeLee & Charnley and Gruen zones"