"Caffey disease is a type I collagenopathy. Both familial and sporadic forms exist. There is evidence to suggest that the familial form is inherited in an autosomal dominant fashion with incomplete penetrance and variable expression 2,3."
"Ultrasound "
"MRI "
"Paediatric radiologist John Caffey (1895-1978) 7 first described infantile cortical hyperostosis with colleague William Aaron Silverman (1917-2004) 8 , an American paediatrician, in 1945."
"Ewing sarcoma"
Expected headings
"Phases"
"Early (acute)"
"Subacute"
"Late"
"Long term sequelae"
"Ultrasound "
"MRI "
"Caffey disease is a type I collagenopathy. Both familial and sporadic forms exist. There is evidence to suggest that the familial form is inherited in an autosomal dominant fashion with incomplete penetrance and variable expression 2,3."
"ribs: lateral aspect; ipsilateral pleural effusion may appear"
"in the involved long bones, only the diaphysis is affected, sparing the metaphysis and epiphysis; consequently, the bone becomes spindle-shaped"
"Can show periostitis and soft tissue oedema. It should be stressed that MRI usually does not offer much added-value in advancing the diagnosis 5 unless infection or neoplasia are high on the differential list; indeed, at times, MRI appearance may confound the radiologist. Hence, radiography should be the primary modality of investigation and follow-up."
"Other conditions can usually be excluded based on the narrow age range for the presentation of infantile cortical hyperostosis; the triad of irritability, swelling, and bone lesions; and the presence of mandibular involvement."
"Other conditions can usually be excluded based on the narrow age range for the presentation of infantile cortical hyperostosis; the triad of irritability, swelling, and bone lesions; and the presence of mandibular involvement."
"The carpus, tarsus, phalanges and vertebral bodies are rarely involved."
"infection (e.g. syphilis, tuberculosis)"