"syndrome of inappropriate ADH secretion (SIADH)"
Expected headings
"Agents"
"Pharmacodynamics"
"Pharmacokinetics"
"Side-effects"
"Nephrotoxicity"
"Cardiovascular"
"Gastrointestinal"
"Other"
"Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used class of pharmacological agents in the world; aspirin is in this class. They are extremely efficacious medications for pain and the inflammatory response. Their primary mechanism occurs by inhibiting the enzyme cyclo-oxygenase, which coexists in two main isoforms, COX-1 and COX-2. They have significant side-effects, which include gastrointestinal bleeding, cardiovascular toxicity, and renal impairment."
"COX-1 is important for the production of prostaglandins which are key to the integrity of the gastrointestinal mucosa, the maintenance of renal function, platelet interlinking and other key homoeostatic actions. COX-2 is central to the synthesis of prostaglandins key to pain, fever and the inflammatory response. Thus ideally NSAIDs maximise their COX-2 inhibition, therefore blunting inflammation, but minimise their effects upon COX-1 activity, thus decreasing the risk of adverse effects."