"Due to its antiplatelet effects aspirin is associated with increased bleeding especially in higher doses or with chronic use. Care has to be taken in its use in children and adolescents. Side effects include the following:"
"Protein binding in the blood is concentration-dependent with approximately 50–80% of salicylate bound to albumin and the rest remaining ionised and active."
"increased risk of GI bleeding compared to ibuprofen"
"asthma and NSAID-induced bronchospasm"
"Salicylates in the form of willow leaves (genu Salix) have been used as medicine for more than three millennia. Hippocrates already referred to their antipyretic properties and the first record of use as an analgesic the Ebers papyrus goes back to 1534 BC 12,13."
Expected headings
"Clinical usage"
"Contraindications"
"Side effects"
"Toxicity"
"Treatment and prognosis"
"Interactions"
"Pharmacology"
"Pharmacodynamics"
"Pharmacokinetics"
"Aspirin is an effective analgesic, antipyretic and anti-inflammatory agent 3,4. It also has an antithrombotic effect by inhibiting platelet function and low-dose aspirin has a central role in antiplatelet therapy in the setting of acute and chronic coronary syndromes. Clinical uses are as follows 3-10:"
"Beyond its anti-inflammatory, analgesic and antiplatelet mechanisms, acetylsalicylic acid is considered to be anti-carcinogenic and anti-proliferative on vascular smooth muscle cells."