"T1: useful for detection of prostate contour, neurovascular bundle encasement, and post-biopsy haemorrhage 15"
"DWI/ADC: usually shows restricted diffusion, especially on higher grade tumours"
"dynamic contrast enhancement (DCE): (dynamic contrast enhancement in prostate cancer)"
"T1: useful for detection of prostate contour, neurovascular bundle encasement, and post-biopsy haemorrhage 15"
"involves post-processing time"
"fluorine-18-PSMA PET can also be used for diagnosis, staging, restaging and evaluation of therapy response. Fluorinated tracers have a longer half-life and are therefore more practical than gallium tracers."
"The aim of prostate MRI is to detect clinically significant prostate cancer, as insignificant prostate cancer is common 35. However, this term is without a consensus definition 35,36 (c. 2024) and has been defined as one or more of the following (noting variability within criterion) 31-35:"
"The aim of prostate MRI is to detect clinically significant prostate cancer, as insignificant prostate cancer is common 35. However, this term is without a consensus definition 35,36 (c. 2024) and has been defined as one or more of the following (noting variability within criterion) 31-35:"
"Gleason score >6 or ≥7"
"The TNM staging system is used for staging prostate cancer. Prostate cancer is one of the (less common) causes of cannonball metastases to the lung."
"Micro-ultrasound (microUS) uses a high-frequency probe to assist in differentiating between benign and malignant lesions and targeting lesions for biopsy. A PRI-MUS score is given to assess the probability of the lesion being malignant 37."
"Often, a PI-RADS score is given to assess the probability of the lesion being malignant."
"Ga-68-PSMA PET"
"gallium-68-PSMA PET can be used for diagnosis, staging, restaging, evaluation of therapy response and prognostication in prostate cancer 26"
"F-18 PSMA PET"
"fluorine-18-PSMA PET can also be used for diagnosis, staging, restaging and evaluation of therapy response. Fluorinated tracers have a longer half-life and are therefore more practical than gallium tracers."
"in patients with low PSA levels, F-18 PSMA PET or Ga-68 PSMA PET is superior in detecting prostate cancer metastases compared to PET performed with other radiotracers 29"
"in patients with low PSA levels, F-18 PSMA PET or Ga-68 PSMA PET is superior in detecting prostate cancer metastases compared to PET performed with other radiotracers 29"
"FDG PET may be used for PSMA-negative patients with aggressive cancer or to assess recurrence 30"
"Patients who do not meet these criteria will usually undergo a combination of androgen deprivation therapy, immunotherapy, radiotherapy, or chemotherapy. Theranostic approaches, including PSMA-targeted therapies, e.g. lutetium-177 vipivotide tetraxetan, are increasingly emerging for prostate cancer management, particularly intractable metastatic disease."
"MR spectroscopy"
Expected headings
"Staging"
"Signal characteristics"
"MR spectroscopy"
"Tc-99m MDP bone scan"
"Ga-68-PSMA PET"
"F-18 PSMA PET"
"F-18-fluciclovine PET"
"F-18 FDG PET"
"an elevated (greater than 4 ng/mL) prostate-specific antigen (PSA); normal is 1-4 ng/mL"
"Prostate cancer can spread by local invasion (typically into the bladder and seminal vesicles; urethral and rectal involvement are rare), lymphatic spread (pelvic nodes first followed by para-aortic and inguinal nodes), or by haematogenous metastases 23. Common sites of haematogenous metastases are 22,23:"
"The addition of MR spectroscopy (MRS) with fast T2-weighted imaging has been an area of research for a long time now, but has not become widely established in everyday clinical practice. The normal prostate produces a large amount of citrate from the peripheral zone, which tumours do not 3. In normal prostate tissue, citrate and polyamine levels are high, and choline levels are low. The reverse is the case in a tumour."
"fluorine-18-PSMA PET can also be used for diagnosis, staging, restaging and evaluation of therapy response. Fluorinated tracers have a longer half-life and are therefore more practical than gallium tracers."
"other prostatic tumours: rare (e.g. melanoma of prostate 9)"