"Ktrans is a measure of capillary permeability obtained using dynamic contrast-enhanced (DCE) MR perfusion. It is calculated by measuring the accumulation of gadolinium-based contrast agent in the extravascular-extracellular space."
"It should be noted that how ktrans is interpreted varied according to permeability and blood flow. In situations where permeability is very low (near-intact blood brain barrier) then ktrans is a useful measure of permeability, whereas in situations where permeability is very high (disrupted blood brain barrier) then ktrans will reflect blood flow 3."
Expected headings
"Extracranial usage"
"glioma: VEGF produced by the tumour reduces the effectiveness of gap junction and creates fenestrations in the endothelium of brain capillaries; this has been shown to correlate with tumour grade 1"
"inflammatory lesions (e.g. demyelinating plaques of multiple sclerosis)"