"T2: most exhibit very high signal"
"SWI/GE: variable intralesional haemorrhage, suggested by the presence of blooming artifact"
"conventional chordoma: 1474 ± 117 x 10-6 mm2/s 13"
"dedifferentiated chordoma: 875 ± 100 x 10-6 mm2/s 13"
"higher ADC values: 2051 ± 261 x 10-6 mm2/s 13"
"conventional chordoma: 1474 ± 117 x 10-6 mm2/s 13"
"dedifferentiated chordoma: 875 ± 100 x 10-6 mm2/s 13"
"higher ADC values: 2051 ± 261 x 10-6 mm2/s 13"
"PIK3CA signalling mutations"
"usually hyper-attenuating relative to adjacent brain; however, inhomogenous areas may be seen due to necrosis or haemorrhage"
"SWI/GE: variable intralesional haemorrhage, suggested by the presence of blooming artifact"
"Although angiography is useful to assess vascular encasement and displacement, chordomas usually do not have significant tumoural vascularity 3."
"heterogenous T2 signal"
Expected headings
"Sacrococcygeal"
"Spheno-occipital"
"Vertebral bodies"
"Chordomas can occur at any age but are usually seen in adults (30-70 years). Those located in the spheno-occipital region most commonly occur in patients 20-40 years of age, whereas sacrococcygeal chordomas are typically seen in a slightly older age group (peak around 50 years 10). There is an overall male to female predilection of 2:1 3. Although some publications have reported greater numbers of white patients being diagnosed with chordoma, differences in incidence rates by ethnicity have not been established 17."
"Macroscopically, chordomas present as firm masses. Fluid and gelatinous mucoid substance (associated with recent and old haemorrhage) and necrotic areas are found within these tumours. In some patients, calcification and sequestered bone fragments are found as well. The variety of these components may explain the signal heterogeneity observed on MRI."
"Metastatic spread of chordomas is observed in 7-14% of patients and includes nodal, pulmonary, bone, cerebral or abdominal visceral involvement, predominantly from massive tumours 12."
"The clival region is the second most common location, accounting for 30-35% of cases 2,3. Typically the mass projects posteriorly at midline, indenting the pons; this characteristic appearance has been termed the so-called thumb sign. In contrast to sacrococcygeal tumours, there is no recognised gender difference."
"usually hyper-attenuating relative to adjacent brain; however, inhomogenous areas may be seen due to necrosis or haemorrhage"
"Histological subtype also has a substantial impact on prognosis with chondroid chordoma having the best prognosis and dedifferentiated chordoma the worst prognosis; the more common conventional chordoma having intermediate prognosis 14,15."
"hypointense on T1; variably hyperintense on T2"