"T2/FLAIR: diffuse high signal in white matter, particularly in the centrum semiovale, subcortical U-fibres are often spared 2,4"
"DWI/ADC: diffusion restriction, often marked 1,3,4"
"T1: affected white matter is typically iso- to hypointense"
"T1 C+ (Gd): no enhancement"
"NAA peak decreased 2"
"The diagnosis requires a prolonged and severe period of cerebral hypo-oxygenation, from which the patient initially recovered 1-4. After a period of relative stability that lasts typically days to weeks, there is an acute progression of neuropsychiatric deficits characterised by confusion, abnormal behaviour, parkinsonism and other movement disorders, and cognitive deficits 1-4."
"toxic leukoencephalopathies (e.g. heroin-induced leukoencephalopathy, methotrexate-related leukoencephalopathy)"