"While the natural history remains poorly defined, there is broad agreement that untreated lesions can lead to severe clinical manifestations (e.g. macrocephaly, heart failure, elevated intracranial pressure, and increased haemorrhagic risk) 1."
Line 40:146·An e.g. list gives selected examples, so it should not end with 'and' or 'or': 'e.g. macrocephaly, heart failure, elevated intracranial pressure, and'.