"T1: hypointense"
"T2: hyperintense"
"EWSR1-SMAD3-positive fibroblastic tumours are benign mesenchymal neoplasms with different morphologies and a provisional name 1-4 that was and added to the WHO classification of soft tissue tumours in 2020 2,3."
"EWSR1-SMAD3-positive fibroblastic tumours are sporadic soft tissue neoplasms. They appear in a wide age range, with women more commonly affected than men 2."
"The diagnosis of EWSR1-SMAD3-positive fibroblastic tumours is established by location, histological, immunohistochemical, and molecular criteria 1."
"EWSR1-SMAD3 fusion"
"EWSR1-SMAD3-positive fibroblastic tumours usually present as painless, small, superficial nodules in an acral location in the hands and/or feet 1,3."
"EWSR1-SMAD3-positive fibroblastic tumours are characterised by a zonal morphology of intersecting cellular fascicles composed of monomorphic spindle cells and hypo to acellular hyalinised areas 1-4."
"EWSR1-SMAD3-positive fibroblastic tumours are most commonly located in the skin or the subcutaneous tissue of the hands and feet 1-4."
"Histologically EWSR1-SMAD3-positive fibroblastic tumours display the following characteristics 1-4:"
"Those tumours are characterised by genetic EWSR1-SMAD3 fusions 1."
"EWSR1-SMAD3-positive fibroblastic tumours have been first described by the Taiwanese pathologist Yu-Chien Kao and his American and Dutch colleagues Lei Zhang, Yun-Shao Sung, Albert JH Suurmeijer and Cristina R Antonescu 1."
"Conditions that can mimic the presentation and/or the appearance of EWSR1-SMAD3-positive fibroblastic tumours include the following:"
"EWSR1-SMAD3-positive fibroblastic tumours are sporadic soft tissue neoplasms. They appear in a wide age range, with women more commonly affected than men 2."
"The diagnosis of EWSR1-SMAD3-positive fibroblastic tumours is established by location, histological, immunohistochemical, and molecular criteria 1."
"immunoreactivity to ERG"
"Immunohistochemistry stains show diffuse nuclear reactivity for ERG, but do not express CD34 or smooth muscle actin 1,2,4."
"EWSR1-SMAD3-positive fibroblastic tumours have been first described by the Taiwanese pathologist Yu-Chien Kao and his American and Dutch colleagues Lei Zhang, Yun-Shao Sung, Albert JH Suurmeijer and Cristina R Antonescu 1."
Expected headings
"Signal characteristics"
"absence of nuclear pleomorphism, hyperchromasia and increased mitotic activity"
"History and etymology"