"Familial adenomatous polyposis syndrome results from mutation of the tumour suppressor adenomatous polyposis coli (APC) gene located on chromosome 5q21-2. Around one-third of cases are thought to be sporadic (i.e. no family history) and two-thirds are thought to be familial 1."
"MUTYH gene mutations have been associated with APC-negative familial adenomatous polyposis syndrome; which has an autosomal recessive inheritance 6 and is termed MUTYH-associated polyposis (MAP)."
Expected headings
"Variants"
"Associations"
"MUTYH gene mutations have been associated with APC-negative familial adenomatous polyposis syndrome; which has an autosomal recessive inheritance 6 and is termed MUTYH-associated polyposis (MAP)."
"There are several variants of familial adenomatous polyposis syndrome:"