"It is named after Jacques Turcot (1915-1977) 5, a Canadian surgeon."
"It is thought to carry an autosomal recessive inheritance. Two-thirds of patients have mutations in the APC gene, the same genetic defect as in familial adenomatous polyposis (FAP). These patients have multiple colonic adenomas, and virtually all develop colorectal cancer by the age of 40. The common intracranial tumour in this subtype is medulloblastoma."
"The other third have mutations in the HNPCC genes. Colonic malignancy is not as common in this type but tends to develop at a younger age. Most develop glioblastomas."