"Colchicine is the primary therapy and in the pre-colchicine era, the prognosis was very poor. In addition to colchicine, anti-interleukin-1 (anti-IL-1) agents, specifically canakinumab 7,8, may be used in patients resistant or unresponsive to colchicine treatment."
"Familial Mediterranean fever is a single gene defect disorder with an autosomal recessive pattern of inheritance. The MEFV gene is found on chromosome 16p13.3 and it encodes a protein named pyrine. Pyrine is important in the regulatory control of apoptosis and inflammation, however its physiology is still being unravelled. Point mutations in MEFV are typically found in those with familial Mediterranean fever."
"The diagnosis of familial Mediterranean fever is usually not considered by radiologists/clinicians unless there is a known history of the condition."
Expected headings
"Laboratory markers"