"Pathology "
"T1: isointense to hyperintense"
"T2/FLAIR: hyperintense"
"T1 C+ (Gd): usually no enhancement, although enhancing FASI (including potential of regression over time) have been reported 13"
"MR spectroscopy: normal (useful to distinguish from tumours 9)"
"Typically FASI have been described to not have mass effect or enhancement. They most commonly occur in the basal ganglia, brainstem, thalamus, optic tracts, cerebellum, and infrequently cerebral hemispheres 11,12."
Expected headings
"Pathology "
"Focal areas of signal intensity (FASI), also known as focal abnormal signal intensity or unidentified bright objects (UBO), are bright areas on T2-weighted images commonly identified in the basal ganglia (often the globus pallidus), thalamus, brainstem (pons), cerebellum, and subcortical white matter in children with neurofibromatosis type 1 (NF1)."
"Focal areas of signal intensity (FASI), also known as focal abnormal signal intensity or unidentified bright objects (UBO), are bright areas on T2-weighted images commonly identified in the basal ganglia (often the globus pallidus), thalamus, brainstem (pons), cerebellum, and subcortical white matter in children with neurofibromatosis type 1 (NF1)."
"Typically FASI have been described to not have mass effect or enhancement. They most commonly occur in the basal ganglia, brainstem, thalamus, optic tracts, cerebellum, and infrequently cerebral hemispheres 11,12."
"There is controversy about the relationship of FASI with cognitive dysfunction in NF1 3. Some studies in the early 2000s suggested a relationship between cognitive impairment, and the presence, number, and location of FASI, but only thalamic lesions seem to be strongly associated with cognitive impairment 3-6."
"There are case series that show that occasionally FASI can have mass effect/enhancement, and in these cases the FASI become difficult to distinguish from a low-grade glioma."